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In this study we have investigated the role of B cells and macrophages in immunoprotection during murine cutaneous leishmaniasis. The results indicate that, in contrast to the Th1 protective response that required both CD4 and CD8 T cells, a Th2 protective response is only effective when both B cells and macrophages are present. In addition, B cells are critical for the generation of Th1 cytokine-producing cells. The requirement for B cells in the induction of a Th1 protective response and for macrophages in the establishment of a Th2 protective response is of particular significance in terms of leishmaniasis treatment and prevention.Houston Dynamo defender Leonardo will be returned to the club on loan for the remainder of the 2014 MLS season, the club announced today. The Venezuelan defender originally joined the Dynamo on loan in June, but with the impending expiration of his loan agreement, Houston exercised their right to recall the player earlier this month. 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